This opportunity funds discovery research to identify small molecules that elucidate disease biology or act as therapeutic or immunomodulatory agents. Supported activities include assay development for biological targets, implementation of high or moderate throughput screening, hit validation with orthogonal assays and cheminformatics, and hit-to-lead optimization involving SAR, ADME, PK/PD studies, and in vivo efficacy modeling when appropriate.
Eligible applicants include Native American tribal organizations, nonprofits, state and local governments, institutions of higher education, small businesses, and for-profit organizations other than small businesses. See official guidelines for full details.
