This funding opportunity supports investigator-initiated mid-phase clinical trials of natural products, including botanicals, dietary supplements, and probiotics. Applications should focus on determining optimal dosing or identifying patient phenotypes for future efficacy trials. Trials must be hypothesis-driven, milestone-based, and exclude cancer treatment or prevention studies. Preliminary data on bioavailability and target engagement is required unless waived. Contact NCCIH research staff before applying.
Eligible applicants include Native American tribal organizations, various government entities, nonprofits, small businesses, and institutions of higher education. Specific eligibility details are provided in the full announcement.
