This funding opportunity supports exploratory research projects that focus on undruggable target classes within intractable human diseases. It encourages development of innovative methods or agents selective for these targets, aiming to overcome challenges in current therapeutic approaches. Clinical trials are not allowed under this mechanism, emphasizing early-stage discovery and method development.
Eligible applicants include a wide range of organizations such as nonprofits, small businesses, various government entities, private and public institutions of higher education, tribal organizations, and others. Foreign entities and foreign components of U.S. organizations are not eligible.
