This award supports individual scientists or groups proposing exceptionally innovative and unconventional biomedical research with the potential to create new scientific paradigms, improve clinical approaches, or develop transformative technologies. Projects may be basic, translational, or clinical and do not require preliminary data. The award is part of NIH's High-Risk, High-Reward Research program and aims to fund research with broad relevance and major impact potential.
Eligible applicants include a wide range of organizations such as public and private higher education institutions, government entities, nonprofits, small businesses, and tribal organizations. Foreign organizations are not eligible to apply, though foreign components of U.S. organizations are allowe
