This funding opportunity supports large-scale pragmatic and implementation trials conducted in diverse health care settings to evaluate the effectiveness and delivery of biomedical or behavioral interventions embedded in routine care. Trials should inform patients, clinicians, administrators, policymakers, and payers about comparative benefits, burdens, and risks. Applicants are encouraged to select common care settings, include multiple health system types, and assess intervention adaptation across regions. The award uses a milestone-driven cooperative agreement mechanism with planning and ex
Eligible applicants include state and county governments, tribal governments and organizations, nonprofits, private and for-profit institutions, small businesses, federal agencies, U.S. territories, faith-based and community organizations, regional organizations, and foreign institutions.
