This funding opportunity supports high-impact patient-centered comparative clinical effectiveness research projects, including randomized controlled trials, natural experiments, and observational studies. It emphasizes intervention implementation to facilitate widespread uptake and requires clinically meaningful, patient-important outcomes. Special focus areas include cancer symptom management, serious mental illness, mental health and substance use in pregnancy/postpartum, and sensory health conditions. Applicants may select up to three topic themes within PCORI's Research Project Agenda.
Eligibility criteria are not specified in the announcement.
